Genesis 4:12

‘When you work the ground it will no longer yield to you its fruit, you will be a fugitive and wanderer on the earth.'

He is to be banished to a place where the ground is totally unfruitful, driven as a consequence of his own sin. There will be nowhere for him to go, for his blood will be sought by the whole family of men. The only safe place will be the ‘land of wandering (nod)', the desert where nothing can be grown and a man must be constantly on the move in order to find food and water. This is confirmation that there are many children of Adam and Eve by this time.