Mark 15:23

‘And they offered him wine mingled with myrrh and he did not receive it.'

Theophrastus and Pliny both mention the custom of mixing wine with myrrh, but here the purpose was probably to dull the senses so that the extreme pain might be somewhat relieved. The Talmud later mentions this custom (based on Proverbs 31:6), a ministry carried out by pious women of Jerusalem. If so the offer was sympathetic and friendly. But Jesus did not receive it. He knew that He needed to be fully aware for He had to drink to the full another cup, the cup He had voluntarily taken to His mouth in Gethsemane.

On the other hand ‘they' in context means the Roman soldiers. That would not necessarily exclude the women as a kind hearted Roman soldier might quite easily have assisted the women in getting the drink to Jesus. (Not all Roman soldiers were brutes). It is not likely that the soldiers themselves would have had wine mingled with myrrh.