Psalms 22:14

‘I am poured out like water, and all my bones are out of joint. My heart is like wax, it is melted within me.'

The inevitable effects of crucifixion were having their effect. His body was being weakened as the blood poured from His many wounds like water, and as His body was twisted and stretched by the cross, His bones became distorted and out of joint, while His heart within Him was like melted wax, as a result of His sufferings, and at the awfulness of the burden of sin that He faced.