Romans 8:7,8

‘Because the mind of the flesh is enmity against God, for it is not subject to the law of God, nor indeed can it be, and those who are in the flesh cannot please God.'

And this is because having the mind of the flesh is to be at enmity with God. That which is fleshly is not subject to the Law of God, nor indeed can it be, for the Law is spiritual (Romans 7:14). This underlines the fact that the descriptions in Romans 7:22 were of regenerated men and women. That a battle was taking place was because the Spiritual mind was being applied rather than the fleshly one. As a consequence of all this, those who are ‘in the flesh' cannot please God. God cannot look with pleasure on one who is deliberately dwelling in the realm of the flesh and walking in deliberate disobedience. They are enemies of God. They are not subject to God's Law (they are criminals and rebels). They cannot please God. And the reason why this is so, is because all that they do, even if it has to do with high level morality, is done out of fleshly motives.