Ephesians 6:18

Praying always; i.e. in every opportunity, so often as our own or others necessities call us to it, 1 Thessalonians 5:17. With all prayer and supplication; prayer, when opposed to supplication, seems to signify petitioning for good things, and supplication the deprecating of evil, 1 Timothy 2:1. In the Spirit; either our own spirit, with which we pray, so as not to draw nigh to God with our mouth only, as Isaiah 29:13; or rather, the Holy Spirit of God, by whose assistance we pray, Romans 8:26,27 Jude 1:20. Watching thereunto; to prayer, in opposition to sloth and security: see Matthew 26:41 Colossians 4:2 1 Peter 4:7. With all perseverance; constancy and continuance in prayer in every condition, adverse as well as prosperous, though prayer be not presently answered, Luke 18:1. And supplication for all saints; not only for ourselves, but for our brethren in the world, none being in so good a condition but they may need our prayers.