Revelation 6:8

A pale horse; a horse of the colour of his rider, Death, which makes men look pale, and bringeth them into the state of the dead, (here translated hell), whether heaven or hell, as they have lived. And power was given unto them over the fourth part of the earth; over a great part of the earth. To kill with sword, and with hunger, and with death, and with the beasts of the earth; to kill men all manner of ways, with the sword, famine, pestilence, and by throwing them to wild beasts. Interpreters judge that here was prophesied what should happen to the Roman empire, and the church within it, from the time when Maximinus was made emperor, which was about the year 237, to the time of Aurelianus, which was about 271. Some extend it to Dioclesian's time, which ended about 294; but Mr. Mede rather reserveth that for the fifth seal. If the former time only be taken in, there was within it the seventh, eighth, and ninth persecutions; Dioclesian began the tenth and greatest of all. Within this time this prophecy was eminently fulfilled: Maximinus destroyed all the towns in Germany, for three or four hundred miles. There was a plague lasted fifteen years together in the time of Gallus, who had the empire Anno 255. Three hundred and twenty thousand Goths were slain by Flavius Claudius. Maximinus and Gallienus were both great butchers, both to their own subjects that were heathens, and to Christians. Gallienus is said to have killed three or four thousand every day. Such wars and devastations could not but be followed with famine; besides that we are confirmed in it, both by the testimony of Eusebius and Cyprian, the latter of whom lived within this period.