Isaiah 53:6

All we like sheep have gone astray; we have turned every one to his own way; and the LORD hath laid on him the iniquity of us all.

Ver. 6. All we, like sheep, have gone astray.] Gone of our own accords, as "longing to wander"; Jer 14:10 to wander as sheep, lost sheep, than the which no creature is more apt to stray, and less able to return. "The ox knoweth his owner, and the ass his master's crib. "The very swine accustomed to the trough, if he go abroad, yet at night will find the way home again. Not so the silly sheep. "Lo, ye were all as sheep going astray," saith Peter, "but are now returned unto the Shepherd and Bishop of your souls." 1Pe 2:25

We have turned every one to his own way.] Quo variae errorum formae innuuntur, dum suas quisque opiniones sectatur. Each one, as he is out of God's way, so hath his own by way of wickedness to wander in; wherein yet, without a Christ, he cannot wander so far as to miss hell.

And the Lord hath laid on him the iniquity of us all,] i.e., Of all his elect. The iniquity of us all he hath made to meet on him, so the Hebrew hath it; or, To light on him, even the full weight of his wrath and dint of his displeasure, for our many and mighty sins imputed unto him. Let the Jew jeer at this and say, that every fox must pay his own skin to the flayer; let the Romanist reject imputed righteousness, calling it putative, by a scoff; there is not anything that more supporteth a sinking soul than this "righteousness which is through the faith of Christ, the righteousness which is of God by faith." Php 3:9 This manus Christi, as nailed to the cross, is the only medicine for a sin sick soul, believe it.