Acts 20:23

πλὴν ὅτι … διαμαρτύρεταί μοι, save that the Holy Ghost witnesseth unto me in every city. The Holy Ghost had called him to the work (Acts 13:2) and moved the disciples (Acts 21:4) and Agabus (Acts 21:11) to warn him of the sufferings which were at hand. We may suppose too that such warnings came more frequently than St Luke has recorded them.

δεσμὰ καὶ θλίψεις, bonds and afflictions. The two nouns are combined in Philippians 1:16 θλιψιν ἐπιφέρειν τοῖς δεσμοῖς μου, where the sense is most probably ‘to add mental grief to my bodily suffering in prison.’ Such ‘afflictions’ are harder to bear than any ‘bonds.’