Genesis 42:22

And Reuben answered See Genesis 37:21-22. Reuben, according to E, believed Joseph to have been killed (Genesis 37:30), and had no knowledge of his being "kidnapped." He can appeal to good intentions, but not to courageous action.

his blood is required For this phrase see note on Genesis 9:5. Cf. 2 Chronicles 24:22. His disappearance meant to his brethren his death. Reuben's interference had prevented them from shedding Joseph's blood (Genesis 37:22), but they were morally guilty of his life.