Isaiah 24:5

The earth also is defiled(literally, profaned) under the inhabitants thereof That the land of Israel is profaned by the sins of its people, is a prominent idea in the O.T.; the conception is here extended to the whole earth. The condition of the world resembles that which preceded the Deluge (Genesis 6:11).

changed the ordinance Rather, disregarded (lit. "passed by") the ordinance.

the everlasting covenant The expression is taken from Genesis 9:16, and refers to the covenant made after the flood with Noah and his family as representatives of the human race. The sin of the world lies in the violation of these fundamental dictates of morality, especially the law against murder, which is the principal stipulation of the Noachic covenant (Genesis 9:5-6). The conception is probably a late one.