Isaiah 57:10,11

Although wearied by these idolatries they have persisted in them with an infatuation which has blinded them to their desperate situation, and rendered them indifferent to the fear of Jehovah.

in the greatness of thy way i.e. "through thy much wandering," thy multifarious religious observances.

There is no hope Lit. "desperatum est"; cf. Jeremiah 2:25; Jeremiah 18:12 (with a somewhat different shade of meaning).

thou didst find the life of thine hand A very obscure and variously explained phrase. R.V. a quickening (i.e. renewal) of thy strength is perhaps the most feasible interpretation, but the peculiar expression is hardly accounted for, unless it be a current proverb.

thou wast not grieved lit. sick, weak and faint. Comp. Jeremiah 5:3, "Thou hast smitten them and they did not become sick," i.e. did not feel weak.