Job 10:3

is it good unto thee The usual meaning of the phrase is, Is it thy pleasure, does it seem right to thee? Deuteronomy 23:17. The words might also mean, Is it becoming thee? Exodus 14:12. The former sense suits the connexion better, because Job is groping after the discovery of some characteristic or quality in God to account for his afflictions.

the work of thine hands No doubt both Job and the wicked were all the work of God's hands, but the righteous are in such a special sense the work of His hands that here they are so described in opposition to the wicked.