Job 16:8

The verse reads,

Thou hast laid hold of me, and it is become a witness against me;

And my leanness riseth up against me; it beareth witness to my face.

By God's seizing or laying hold of him Job means his afflictions. These afflictions sent by God were assumed by all to be witnesses of his guilt; his emaciation from disease rose up and testified to his face that he was a sinner. Such was the construction all men put on his calamities, and under this impression they all turned away from him, thinking him one stricken of God and afflicted (Isaiah 53:4). See on ch. Job 1:11, and cf. Isaiah 3:9.