Deuteronomy 28:45

45.Moreover, all these curses shall come upon thee. He not only confirms what he has already said, but takes away all hope of alleviation, since God’s scourges shall not cease until they have repented. He declares that all the curses shall come upon them; for although they are not always congregated into a single band, still it is true that God pays the wages of the transgressors of His Law with this multitude of miseries which Moses has recounted. By the word pursue, he takes away all hope of escape, whilst to overtake is equivalent to laying hold of them tenaciously, till, as it is further said, they be destroyed. The sum is, that the ungodly by their subterfuges only bring it to pass that they accumulate upon themselves heavier punishments, which will never cease to afflict them until they are destroyed by them. For this reason, he says that they shall be “for a sign and a wonder,” i e. , that they shall awaken astonishment in all men; for those who are but little moved by the common and ordinary judgments of God, are compelled, whether they will or no, to give attention to these prodigies. Thus, notable punishments, and such as are worthy of special observation, are “for a sign and a wonder.”

Their ingratitude is also reproved as well as their contempt of the Law, because they served not God “with joyfulness and gladness of heart,” when He had been so abundantly generous to them; for it is the fault of a corrupt and malignant nature, that it should not be possible to bring it to serve God joyfully, when He invites us by His liberality. But Moses takes it for granted that, since God will prevent the Israelites with His favor, before He proceeds to inflict punishments upon them, they will be guilty of this brutal sin, not to allow themselves to be liberally sustained by Him.