Daniel 11:5

And the king of the south, &c. “Though the kingdom of Alexander was divided into four principal parts, yet only two of them have a place in this prophecy, Egypt and Syria. These two were by far the greatest and most considerable, and at one time were, in a manner, the only remaining kingdoms of the four; the kingdom of Macedon having been conquered by Lysimachus, and annexed to Thrace, and Lysimachus again having been conquered by Seleucus, and the kingdoms of Macedon and Thrace annexed to Syria. These two, likewise, continued distinct kingdoms after the others were swallowed up by the power of the Romans. But there is a more proper and peculiar reason for enlarging on these two particularly; because Judea, lying between them, was sometimes in the possession of the kings of Egypt, and sometimes of the kings of Syria; and it is the purpose of Holy Scripture to interweave only so much of foreign affairs as hath some relation to the Jews; and it is in respect of their situation to Judea, that the kings of Egypt and Syria are called the kings of the south and the north.” Bishop Newton.

The king of the south shall be strong, and one of his princes That is, of Alexander's princes. “There is manifestly either some redundance,” says Bishop Newton, “or some defect in the Hebrew copy, which should be rendered, as it is by the LXX., And the king of the south shall be strong, and one of his princes shall be strong above him.” The king of the south, Ptolemy, son of Lagus, called Soter, that is, saviour, the first king of Egypt, and the first founder of the famous library at Alexandria, was indeed very strong: for his dominion extended over Libya, Cyrene, Palestine, Cyprus, some Grecian islands, and Asiatic provinces. His wealth and strength are celebrated by Theocritus in one of his idyls, and by Appian the historian. But still the king of the north, or Seleucus Nicator, that is, the conqueror, was strong above him: for having annexed, as we have seen, the kingdoms of Macedon and Thrace to the crown of Syria, he had become master of three parts out of four of Alexander's dominions. All historians agree in representing him, not only as the longest liver, but likewise as the most powerful of all Alexander's successors. Appian in particular, enumerating the nations which he subdued, affirms that, after Alexander, he possessed the largest part of Asia; for that all was subject to him from Phrygia to the river Indus, and beyond it. He built Seleucia on the Tigris, and many other very considerable cities in India, Scythia, Armenia, and various parts of his wide empire; so that his dominion was indeed a great dominion. He was also, according to Appian, a person of such great strength, that, laying hold on a bull by the horn, he could stop him in his full career: the statuaries, for this reason, made his statue with two bulls' horns on his head. This prince, “having reigned seven months after the death of Lysimachus, over the kingdoms of Macedon, Thrace, and Syria, was basely murdered; and to him succeeded, in the throne of Syria, Antiochus Soter; and to him his son, Antiochus Theus. At the same time, Ptolemy Philadelphus reigned in Egypt after his father, the first Ptolemy. There were frequent wars between the kings of Egypt and Syria, and particularly between Ptolemy Philadelphus, the second king of Egypt, and Antiochus Theus, the third king of Syria.” See Bishop Newton and Wintle.