Genesis 25:23

Two nations are in thy womb The fathers of two nations, namely, of the Edomites and Israelites; two manner of people, which should not only greatly differ from each other in religion, laws, manners, but should contend with each other, and the issue of the contest should be, that the elder should serve the younger, which was fulfilled in the subjection of the Edomites, for many ages, to the house of David.