Daniel 7:6

Lo, another, like a leopard— This third kingdom is that of the Macedonians or Grecians, who, under the command of Alexander the Great, overcame the Persians, and reigned next after them; and it is most fitly compared to a leopard upon several accounts. The leopard is remarkable for its swiftness; and Alexander and the Macedonians were amazingly rapid in their conquest; insomuch, that St. Jerome says, he seems rather to have overrun the world by his victories, than by his battles. The leopard is a spotted animal, and so was a proper emblem of the various nations which Alexander commanded, or of the various manners of Alexander himself; who was sometimes merciful, and sometimes cruel; sometimes temperate, and sometimes drunken; sometimes abstemious, and sometimes incontinent. The leopard is of small stature, but of great courage, so as not to be afraid to engage with the lion, and the largest beasts; and so Alexander, a little king in comparison, and with a small army, dared to attack Darius, the king of kings, whose kingdom extended from the AEgean sea to the Indies. This leopard had upon its back four wings. The Babylonian empire was represented with two wings, but this is described with four: for nothing was swifter than Alexander's conquests, who ran through all the countries from Illyricum to the Adriatic sea, and through a great part of India; not so much fighting, as conquering; and in twelve years subdued part of Europe, and almost all Asia. The beast also had four heads, to denote the four kingdoms into which this third kingdom should be divided, as it was after the death of Alexander among his four captains; Cassander reigning over Macedon and Greece, Lysimachus over Thrace and Bithynia, Ptolemy over Egypt, and Seleucus over Syria. And dominion was given to it, which shews that it was not owing to the fortitude of Alexander, but proceeded from the will of the Lord. And indeed, unless he had been directed, preserved, and assisted by the mighty power of God, how could Alexander, with 30,000 men, have overcome Darius with 600,000, and in so short a time have brought the countries from Greece as far as to India, into subjection? Bishop Newton.