Luke 22:21,22

The hand of him that betrayeth me, &c.— Our Lord, after delivering the sacramental cup, and telling them that his blood was shed for them, mentions the treachery of Judas a second time; and this second declaration came in with peculiar propriety after the institution of the sacrament, which exhibits the highest instance of love to mankind,—his dying to obtain a remission of their sins; for it shewed that the person who could deliberately do so great an injury to so kind a friend, must have been a monster, the foulness of whose ingratitude cannot be reached by the force of language. See the Inferences on Matthew 26.

Luke 22:23. And they began to inquire, &c.— Upon Christ's giving so plain and moving a hint concerning his betrayer, all the disciples, except Judas, were shocked and grieved to think that any one among them should ever commit so base a villainy against their Lord; they were humbly jealous of their own hearts, lest they should deceive them; and were exceedingly solicitous to clear themselves, and to know who it was that should be guilty of this horrible wickedness.