Revelation 16:10-11

The fifth angel poured out his vial upon the seat, &c.— The fifth vial is poured out upon the seat or throne of the beast, and his kingdom becomes full of darkness, as Egypt did under her ninth plague, Exodus 10:21. This is some great calamity which shall fall upon Rome itself, and shall darken and confound the whole antichristian empire. But still the consequences of this plague are much the same as those of the foregoing; for the sufferers, instead of repenting of their deeds, are hardened like Pharaoh, persist in their blasphemy, and obstinately withstand all attempts of reformation.