For the nation and kingdom that will not serve thee shall perish,.... That will not serve the Lord Christ, and worship him with his church and people; that will not be obedient to the laws and ordinances of his house; but appoint another head over them, the pope of Rome; and make other laws, and set up other ordinances, rejecting the authority of Christ, the rule of his word, and the order of his churches:

yea, those nations shall be utterly wasted; even all the antichristian states, when the vials of God's wrath will be poured out upon them; see Zechariah 14:17.

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