Lamentations 3:41

Let us lift up our heart with [our] hands,.... Lifting up of the hands is a prayer gesture, and is put for prayer itself; see

Psalms 141:2; but the heart must go along with it, or it is of no avail; the soul must be lifted up to God; there must be an ascending of that unto him, in earnest desires after him; in affection and love to him; in faith and dependence on him; and in hope and expectation of good things from him, Psalms 25:1; this is the way in which men return to God, even by prayer and supplication. The Targum is,

"let us lift up our hearts, and cast away rapine and prey out of our hands;''

and Jarchi and Abendana mention a Midrash, that paraphrases it,

"let us lift up our hearts in truth to God, as a man washes his hands in purity, and casts away all filthiness from them;''

see Hebrews 10:22;

unto God in the heavens; who has made them, and dwells in them; and therefore prayer must be directed to him, as being there; so our Lord taught his disciples to pray, Matthew 6:9; and which is a very great encouragement to faith in prayer; when it is considered that God is the Maker and possessor of heaven and earth; and that our help is in and expected from him who made all these; and besides the saints have a High Priest, an Advocate with the Father there, to plead their cause for them; and many great and good things are there laid up for them.