Revelation 16:2

And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.

There can be no doubt, but that it was the Lord Jesus Christ, whose voice John heard, as mentioned in the former verse, thus sending forth his servants on their employment; or God the Holy Ghost, whose office it is to ordain to the ministry. In either sense, it is blessed. For in either point of view, it must be attended with success. And most blessed was the success of it. For the effects of the pouring out of the first vial was, that a noisome, and grievous sore, fell upon the men which had the mark of the beast, and upon them which worshipped his image.

The Reader will remember that I do not speak decidedly upon any point of doubtful meaning, but I venture to believe that it was the pouring out of this first Vial, which is said to have been poured upon the earth, that is, the empire of the Pope, which produced a change upon the minds of numbers, concerning him and his heresy. For what is a noisome and grievous sore, in a spiritual sense, but a sense of dissatisfaction. And when the eyes of the common people, here called the earth, through grace, were opened to see the folly of bulls, and grants, and licences, and pardons, all for money, what could sour the mind more, than the having been long hoodwinked by such iniquity.